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Drug features Cost and availability Side effects Drug interactions Warnings Takeaway Introduction Rheumatoid arthritis RA is a condition that can affect many different parts of your body. Methylprednisolone Prednisone What class is it? Cost and availability. Side effects. Drug interactions. Use with other medical conditions. Talk with your doctor. What to Know When Taking Prednisone. Can Prednisone Cause Withdrawal Symptoms?
Steroids for the Treatment of Rheumatoid Arthritis. Read this next. Corticosteroids can be taken by:. Rayos and Medrol are both tablets that are taken by mouth at least once per day. In most cases, your healthcare provider will tell you to taper your dose, gradually reducing it until you are no longer on the medications.
Prednisone and methylprednisone act on the body in very similar ways. The biggest difference between the medications are in regards to dosage and how they are administered. For many people, that means that Rayos can be taken once-daily, while Medrol may require more than one dose per day. Rayos is formulated to take effect during the night. Because of this approach, some people experience a better reduction of inflammation taking Rayos than they do while taking Medrol. Others may prefer Rayos because they only need to take one pill a day, rather than multiple.
Prednisone and methylprednisone were both approved for use by the Food and Drug Administration FDA in the s, and have been used since. Talk to your healthcare provider about the benefits and risks of using either medication long-term to manage your arthritis. Even these substances can interact with corticosteroids. People who are taking prednisone and methylprednisone for arthritis should talk to their healthcare provider about the interactions between these corticosteroids and nonsteroidal anti-inflammatory pain medications , known as NSAIDs.
NSAIDs include prescription medications like:. Rayos and Medrol share many of the same side effects. In the short-term, side effects include:. Occasionally, people on prednisone and methylprednisone can experience serious side effects. The disposition and plasma binding of methylprednisolone were examined in seven normal volunteers following the administration of 5, 20 and 40 mg of intravenous methylprednisolone sodium succinate.
The mean plasma methylprednisolone clearance of ml X h-1 X kg-1 was independent of dose.
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